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Jul 27, 2020

The molecular mechanism of how femoroacetabular impingement (FAI) morphology leads to hip osteoarthritis (OA) is yet to be determined. Expression and location of inflammation-related molecules during early- and late-stage FAI have not been previously described. Moreover, characterization of intraarticular inflammation away from cam deformity as well as the nature of the adjacent synovial tissue has also not been extensively characterized.

In conclusion, hip cartilage exhibits an osteoarthritic phenotype in patients with early FAI similar to what was observed in hip OA secondary to FAI. Severe synovitis was only evident in late-stage disease.


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